Rejuvenate Your Immune System: How Rejuvenate Pro Targets Immunosenescence and Aging Pathways

Aging Immune System – Our Silent Crisis

As we age, our immune system undergoes a process called immunosenescence—a slow deterioration of immune competence that underlies many of the diseases we associate with aging: cancer, cardiovascular disease, neurodegeneration, autoimmunity, and infections. At Aevum Labs, our mission is to combat this immune decline using scientifically-backed ingredients that modulate the very cytokines, chemokines, and cellular pathways driving this process.

Enter Rejuvenate Pro, our advanced formulation that brings together four powerful natural compounds: Immune Defense Proteins (IDP®), Immunel® colostrum extract, Kawakawa leaf, and 20% Carnosic Acid from NZ rosemary. Together, these ingredients help recalibrate the aging immune system, reduce systemic inflammation, and support longer, healthier lives.

1. Immunosenescence, Inflammaging, and the Role of Cytokines & Chemokines

Research from leading institutions such as the Buck Institute and Stanford's 1000 Immunomes Project shows that as we age:

• Pro-inflammatory cytokines like TNF-α and IL-6 increase.

• Anti-inflammatory cytokines like IL-10 decrease.

• Chemokines like CXCL9, a key marker in the iAge clock, become elevated and disrupt immune balance.

• Our thymus gland involutes, leaving us with fewer naïve T cells and more exhausted or senescent immune cells.

This chronic low-grade inflammation—known as inflammaging—is now understood as one of the main drivers of the 12 hallmarks of aging.

2. Rejuvenate Pro: A Systems Biology Approach to Immune Rejuvenation

Rejuvenate Pro was formulated to address these immune-aging mechanisms directly, by combining four synergistic, clinically-researched compounds:

1. IDP® – Immune Defense Protein

• A bioactive whey protein complex rich in lactoferrin, immunoglobulins, and lactoperoxidase.

• Shown to reactivate memory B and T cells in elderly subjects receiving flu vaccines.

• Reduces pro-inflammatory cytokines like TNF-α and IL-6 while supporting tight gut junctions and microbial balance.

• Stimulates naïve T cells, a crucial component lost during thymic involution.

🔬 Study on IDP® improving immune response in older adults

2. Immunel® – Colostrum Extract with Thymic-Like Peptides

• A proprietary colostrum extract that mimics the effects of thymic peptides like Thymosin Alpha 1.

• Supports restoration of thymus-like immune signaling.

• Reduces TGF-β2, a cytokine associated with fibrosis and aging.

• Increases IGF-1 and IL-7, both vital for immune regeneration.

3. Kawakawa (Piper excelsum) – New Zealand’s Indigenous Immune Modulator

• A traditional Māori medicinal plant that acts on the NF-κB pathway, a master regulator of inflammation.

• Proven to reduce IL-6, increase IL-10, and restore immune balance at the genetic transcription level.

• Supports the gut-immune barrier and regulates inflammatory cascades from the top down.

🔬 Kawakawa research on IL-10 and NF-κB modulation

4. Carnosic Acid (20%) – Rosemary Diterpene for Chemokine Control

• A powerful antioxidant and inflammation modulator extracted from NZ rosemary.

• Suppresses key chemokines like CXCL9, CXCL1, CXCL2, and CXCL3, identified as accelerators of immune aging by Stanford's iAge clock.

• Inhibits NF-κB, MAPK, NLRP3, and upregulates SIRT1 and Nrf2, providing systemic anti-inflammatory and cytoprotective effects.

🔬 Review on carnosic acid’s modulation of immune and aging pathways

3. Pathway & Cytokine Targets of Rejuvenate Pro

4. Why This Matters: Slowing Immune Aging = Slowing Biological Aging

Supporting immune resilience is one of the most evidence-backed strategies for increasing healthspan, not just lifespan. By reversing or slowing key hallmarks of immunosenescence, Rejuvenate Pro empowers your body to:

• Fight infections more effectively

• Reduce risk of age-related chronic diseases

• Improve response to vaccines and immune challenges

• Delay systemic degeneration caused by chronic inflammation

5. Backed by Experts, Built for You

This formulation is backed by Dr. Elizabeth Yurth, a world-leading regenerative medicine specialist and longevity researcher from the Boulder Longevity Institute, who also serves as Aevum Labs’ scientific advisor.

🎙️ Watch her deep dive on the science behind immune aging and Rejuvenate Pro

Conclusion: Turn Back Your Immune Clock

Rejuvenate Pro isn’t just another supplement—it’s a precision-formulated longevity tool that addresses the immune system’s central role in the aging process. By modulating the very cytokines and chemokines that define your biological immune age, this advanced blend helps you stay healthier, longer.

Take control of your immune age. Start your rejuvenation journey today.

🔗 Shop Rejuvenate Pro Now