NMNBIO

NMNBIO – TMG 500mg (90 Caps)

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If you're taking NMN to raise NAD+ levels, you need to understand methylation — because NMN uses up methyl groups to do its job. Every time NMN converts to NAD+ inside your cells, the process consumes methyl groups from your body's methylation pool. At lower doses (250mg/day) most people can handle that draw. At higher doses (500mg–1g+/day), or if you're over 40 and your methylation capacity is already declining, you can start depleting SAM (S-adenosylmethionine) — the universal methyl donor your cells need for DNA repair, gene regulation, neurotransmitter synthesis, detoxification, and hundreds of other critical reactions. The clinical signal is rising homocysteine on blood work. The functional signal is brain fog, mood dips, and fatigue — ironically, the same symptoms you started taking NMN to fix.

TMG (trimethylglycine), also called betaine, is a glycine molecule with three methyl groups attached. It's one of the most efficient methyl donors available. TMG enters the methylation cycle through the enzyme BHMT (betaine-homocysteine methyltransferase) in the liver and kidneys, directly converting homocysteine back into methionine — which can then regenerate SAM. This pathway doesn't require folate, B12, or other cofactors in the initial step, which makes TMG particularly valuable when methylation demand is high or cofactor availability is limited.

In plain terms: TMG tops up the methyl groups that NMN is spending. It's not optional if you're serious about NAD+ supplementation at therapeutic doses.

WHAT IT SUPPORTS

Methylation support for NMN users: provides the methyl groups NMN requires for optimal conversion to NAD+. Without adequate methyl donors, NMN efficacy drops and side effects (fatigue, mood changes) can emerge.

Homocysteine regulation: TMG directly lowers homocysteine by donating a methyl group to convert it back to harmless methionine. High homocysteine is an independent risk factor for cardiovascular disease and Alzheimer's. This is testable with a standard blood panel.

DNA repair and gene regulation: methylation is the process by which your cells read and activate the correct parts of your DNA. As methylation capacity declines with age, DNA repair slows, gene expression becomes dysregulated, and cellular ageing accelerates. TMG supports the methyl donor pool that keeps these processes running.

Liver function and detoxification: TMG supports Phase II liver detoxification and has been shown to help support healthy liver fat metabolism and mitochondrial function in the liver.

Cardiovascular health: research on TMG and heart health goes back to the 1950s. By maintaining healthy homocysteine levels, TMG supports vascular integrity and reduces a key driver of arterial inflammation.

Cognitive function and mood: methylation is essential for the synthesis of neurotransmitters including serotonin, dopamine, and noradrenaline. Adequate methyl donor status supports mental clarity, mood stability, and focus.

INGREDIENTS PER CAPSULE

Trimethylglycine Anhydrous (Betaine) — 500mg Also contains: Microcrystalline cellulose (bulking agent), vegetable capsule shell (hydroxypropyl methylcellulose), bamboo silica (anti-caking agent).

Vegan. Non-GMO. Free from gluten, soy, nuts, fish, shellfish, and dairy. Third-party tested and packaged in a GMP and ISO9001-certified UK facility.

DIRECTIONS

Take 1-2 capsules daily with your morning meal, ideally at the same time as your NMN.

NMN Bio recommends the following dosing ratios based on your NMN use:

Starting out on NMN: 1:1 ratio (500mg NMN with 500mg TMG — 1 capsule of each).

After 3-6 weeks: increase to 1:2 ratio (500mg NMN with 1,000mg TMG — 2 capsules TMG).

Long-term NMN users (already supplementing for months): 1:2 or 1:3 ratio (500mg-1,000mg NMN with 1,000mg-3,000mg TMG).

If you're not currently taking NMN, TMG still has standalone value for methylation support, homocysteine management, and liver health. Standard standalone dose: 500mg-1,000mg daily.

TMG is water-soluble and can be taken with or without food. No significant side effects at recommended doses. At very high doses (20g+/day) it can have a mild laxative effect due to its osmoregulatory properties, but this is well above any normal supplementation range.

Not generally recommended for children. If you have a diagnosed methylation disorder (e.g. MTHFR variants), TMG can be particularly valuable — but work with a practitioner who understands your specific methylation profile.

WHO THIS IS FOR

Anyone taking NMN at 500mg/day or higher who wants to maintain methylation balance and maximise NMN efficacy. Anyone with elevated homocysteine on blood work. Anyone with known MTHFR variants who needs additional methyl donor support beyond folate and B12. Anyone wanting to support liver function, cardiovascular health, or cognitive clarity through methylation optimisation. Athletes using NMN for performance and recovery who want to ensure the methylation cycle keeps up with demand.

WHY I STOCK IT

TMG is the essential companion to NMN — and most people taking NMN don't know they need it. I've seen clients start NMN, feel great for a few weeks, then plateau or start feeling flat again. When we check blood work, homocysteine has crept up — their methylation cycle is under pressure. Adding TMG resolves it almost immediately. NMN Bio's version is clean: single-ingredient, pharmaceutical-grade anhydrous betaine, no fillers beyond what's needed for the capsule, third-party tested in the UK. I pair it with Re:juvenate Pro as the anti-inflammatory foundation (you can't methylate efficiently in an inflamed system), and obviously with NMN Bio NMN as the core NAD+ precursor. For the full deep dive on NAD+, NMN, and methylation, listen to the Pushing the Limits podcast.

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